|
KMID : 0861020110260010075
|
|
Korea Journal of Herbology
2011 Volume.26 No. 1 p.75 ~ p.80
|
|
|
Effect of Samhwangsasim-tang, Samigangap-tang and Bangtan-tang on Blood Pressure in Stroke Prone Spontaneously Hypertensive Rats
|
|
Kim Eun-Ju
Kim Hye-Yoom
Lee Jae-Yun
Lee Jun-Kyoung
Kim Seung-Ju
Choi Kyung-Min
Kang Dae-Gil
|
|
|
Abstract
|
|
|
Objectives : The aim of the present study is to investigate the hypotensive effect of Samhwangsasim-tang (SHSST), Samigangap-tang (SMGAT) and Bangtan-tang (BTT) in stroke-prone spontaneously hypertensive rats (SHR-SP).
Methods:SHR-SP rats were treated with SHSST, SMGAT and BTT at dose of 200 mg/kg/day orally for 5 weeks, respectively.
Results:Treatment SHR-SP rats with SMGAT significantly lowered blood pressure but not in the SHSST or BTT treat groups. On the other hand, SHSST, SMGAT and BTT ameliorated endothelium-dependent and independent vascular relaxation in the phenylephrine-precontracted aorta and carotid artery, respectively.
Conclusions : These results indicated that SMGAT has an antihypertensive effect and SHSST, SMGAT and BTT improve vascular function in stroke-prone hypertensive rat model, respectively.
|
|
|
KEYWORD
|
|
|
Samigangap-tang (SMGAT), stroke-prone spontaneously hypertensive rats (SHR-SP), hypertension, eNOS, vascular relaxation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|